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13.2. Somatic mutation rates scale with lifespan across mammals

A Cagan , A Baez-Ortega , N Brzozowska , F Abascal , THH Coorens , MA Sanders , ARJ Lawson , LMR Harvey , S Bhosle , D Jones , RE Alcantara , TM Butler , Y Hooks , K Roberts , E Anderson , S Lunn , E Flach , S Spiro , I Januszczak , E Wrigglesworth , H Jenkins , T Dallas , N Masters , MW Perkins , R Deaville , M Druce , R Bogeska , MD Milsom , B Neumann , F Gorman , F Constantino-Casas , L Peachey , D Bochynska , ESJ Smith , M Gerstung , PJ Campbell , EP Murchison , MR Stratton , I Martincorena

In Brief: To document variations in rates of somatic mutations, the authors performed whole-genome sequencing of DNA from cells of intestinal crypts across 16 diverse mammalian species, spanning huge 40 000-fold variations in body mass and 30-fold variations in lifespan. The somatic mutation rates per year varied greatly across species and showed a much stronger inverse relationship with species lifespan than with species body mass.Comment: Petos p...

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ESPE Yearbook of Paediatric Endocrinology

13.2. Somatic mutation rates scale with lifespan across mammals

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